Eczema/Atopic dermatitis
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Eczema is an inflammatory skin disorder which presents as intensely itchy, dry, inflamed red rashes on the skin. In severe cases the skin can become broken and weepy. Other characteristics are a tendency for the skin to be heavily colonised by bacteria suggesting immune dysfunction and also a tendency for the skin to lichenify in response to rubbing and scratching suggesting membrane fragility.
White blood cells called leucocytes from eczema sufferers tend to have lower levels of a compound called cAMP. This results in increased histamine and decreased bactericidal activity.
Atopic eczema is often regarded as a hereditary condition with a positive family history in many eczema sufferers. It is also often associated with asthma, hay fever or urticaria.
Causes/Contributing factors
A number of factors that may to contribute towards eczema/atopic dermatitis:
- Food sensitivities, intolerances or allergies1
- Intestinal permeability. This is associated with food sensitivities. Intestinal permeability can lead to inappropriate food molecules passing through into the bloodstream causing hypersensitivity reactions2.
- Disordered fat metabolism. One of the things that many people with eczema suffer from is disordered fatty acid metabolism which makes the skin drier and less able to hold onto moisture3 4
- Hypothyroidism
- Nutritional deficiencies such as zinc, vitamin A, vitamin E5 6
- Candida overgrowth7
- Dust mite exposure - this can worsen symptoms8
- Stress9
- Genetic10
Nutritional factors to consider
- Anti-inflammatory diet
- Correction of nutritional deficiencies
- Elimination of problem foods
- If necessary, removal of candida , repair of gut wall and re-innoculation of intestinal microflora
- Modulation of cAMP and decrease of histamine through use of foods and supplements with antihistamine properties eg quercitin and appropriate botanicals
- Immune support
Possible laboratory tests
1 Atherton DJ, Sewell M, Soothill JF, et al. A double-blind controlled crossover trial of an antigen-avoidance diet in atopic eczema. Lancet 1978;1:401-403
2 Majamaa H, Isolauri E. Evaluation of the gut mucosal barrier: evidence for increased antigen transfer in children with atopic eczema. J Allergy Clin Immunol 1996;97:985-990
3 Manku M, Horrobin D, Morse N, et al. Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy. Prostaglandins Leukot Med 1982;9:615-628.
4 Lindskov R, Holmer G. Polyunsaturated fatty acids in plasma, red blood cells and mononuclear cell phospholipids of patients with atopic dermatitis. Allergy 1992;47:517-521
5 David TJ, Wells FE, Sharpe TC. Serum levels of trace metals in children with atopic eczema. Br J Dermatol 1990;122:485-489.
6 Tsoureli-Nikita E, Hercogova J, Lotti T, et al. Evaluation of dietary intake of vitamin E in the treatment of atopic dermatitis: a study of the clinical course and evaluation of the immunoglobulin E serum levels. Int J Dermatol 2002;41:146-150
7 Savolainen J, Lammintausta K, Kalimo K, et al. Candida albicans and atopic dermatitis. Clin Exp Allergy 1993;23:332-339
8 Hanifin JM, Cooper KD, Ho VC, et al. Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)/American Academy of Dermatology Association 'Administrative Regulations for Evidence-Based Clinical Practice Guidelines.' J Am Acad Dermatol 2004;50:391-404
9 Jordan J, Whitlock F. Emotions and the skin: the conditioning of scratch responses in cases of atopic dermatitis. Br J Dermatol 1972;86:574-585
10 Ben-Gashir MA, Seed PT, Hay RJ. Predictors of atopic dermatitis severity over time. J Am Acad Dermatol 2004;50:349-356.